Management of Delayed Chyle Leak after Thyroid Cancer Surgery- A Case Report
Shubham Goel1, Lalit Kumar Bansal2*, Abid Wani1 and Archit Garg1
1ABVIMS and Dr. Ram Manohar Lohia Hospital and Post Graduate Institute of Medical Education and Research, New Delhi
2Department of surgery, ABVIMS and Dr. Ram Manohar Lohia Hospital and Post Graduate Institute of Medical Education and Research, New Delhi
Received Date: 17/08/2020; Published Date: 24/08/2020
*Corresponding author: Lalit Kumar Bansal, Senior resident, ABVIMS and Dr. Ram Manohar Lohia Hospital and Post Graduate Institute of Medical Education and Research, New Delhi.
Cite this article: Shubham Goel, Lalit Kumar Bansal*, Abid Wani and Archit Garg. Management of Delayed Chyle Leak after Thyroid Cancer SurgeryA Case Report. Op Acc J Bio Sci & Res 4(1)-2020.
Chyle leak from thoracic duct injury after head and neck surgery is a rare but severe complication that occurs in about 0.5-1.3% of thyroidectomies and 2-8% after neck dissections. The variable anatomy of the thoracic duct and fragile composition renders it prone to injury during surgery. The majority of chyle leak occurs with surgery of the left neck. However, up to 25% of the chyle leak occurs with right neck surgery. Early identification and appropriate management of chyle leak isnecessary for optimal surgical outcome. In this case report, we explain a case of carcinoma thyroid for which total thyroidectomy with left lateral neck dissection was done. Postoperatively there is continuous drainage of chyle from the wound site, which was managed by re-exploration and repair of the injured thoracic duct.
Keywords: Thyroidectomy; Chyle leak; Thoracic duct injury; Neck dissection
Chyle fistula is defined as a leakage of lymphatic fluid from the thoracic duct or lymphatic branches. It is a rare but potentially devastating and morbid condition .The chylous fistula was first described in the 17th century as complications of trauma . Chyle fistulas most commonly occur secondary to lymphatic disease or malignancy or following abdominal, neck, or thoracic operations .Patients with this condition usually give a history of some comorbid conditions like the history of any malignancy or prior procedures of the chest, neck, or abdomen . In post-operative patients, symptoms onset is found after the start of oral feeding, and also symptoms depend on the site of obstruction .Chyle fistulas can cause severe injury to the patient in the form of loss of fluids, electrolytes, and other nutrients. Also, chyle fistulas can result in loss of lymphocytes and immune dysfunction. Chyle fistulas, due to space-filling with fluid, can exert pressure on surrounding tissues following which symptoms appear that can range from minimaldiscomfort to life-threatening conditions . Lymph vessel damage and lymphatic leakagearetypical after surgery or trauma. However, damaged lymphatics most often heal spontaneously without any significant morbidity. Conservative treatment with nutritional intervention remains the mainstay of treatment.Use of enteral diets with fat restriction or the use of medium-chain triglycerides; medium-chain triglycerides are absorbed directly from the gut into the portal venous circulation .Surgical ligationis the possible treatment when the site of the leak is identified .
A 55-year male admitted tothe surgery department with complaints of left lateral neck swelling in the lastone month. On examination, he has 3x3 cm swelling in the left lateral neck region, non-mobile, firm in consistency, not moved on deglutition or protrusion of the tongue. On FNAC, lateral neck swelling was diagnosed as metastatic lymph node with colloid material in it suggestive of lateral aberrant thyroid. On further investigation, the primary was found in the left lobe of the thyroid, which on FNAC diagnosed as papillary carcinoma of the thyroid. On PET scan, increased FDG uptake was found in thyroid left lobe, central and left II, III, IV, VI level lymph nodes. The right neck lymph node was free from the tumour. Diagnosis of papillary carcinoma thyroid with left lateral neck lymph node metastasis was made based on these findings.
So total thyroidectomy and left lateral and central neck dissection was performed. Bilateral recurrent laryngeal nerve and external laryngeal nerve were preserved. A drain was placed in situ. From post-op day three, there is continuous drainage of chyle, which was gradually increased to around 1 to 1.5 litre per day from 7th post-operative day (Figure 1). The collected fluid was aspirated and sent for biochemical analysis. It shows a high number of triglycerides (1828mg/dl). The diagnosis of chyle leak was made from these observations. So, re-exploration was done. On re-exploration injury was found in one high arched tributary of the left thoracic duct (Figure 2).The injured tributary was successfully ligated, and the leak was stopped. Also, the fibrin sealant was spread. Postoperatively the patient was discharged without any further complication.
Figure-1: Aspiration of the collection which shows milky fluid.
Figure 2: Injuredhigh arched tributary of the left thoracic duct.
The thoracic duct is the largest lymphatic vessel that drains up to 75% of the lymph from the entire left body and the right side of the body below the diaphragm .The thoracic duct is susceptible to accidental injury during dissection low in the neck during various neck dissection surgery. It is more prone for injury due to the variable course and collapsibility of the thoracic duct. Also, patient fasting in preparation for surgery, so, identification of the thoracic duct may be challenging, and injury may be undiagnosed during surgery . Because ofthe presence of multiple terminations, the thoracic duct may be identified and ligated at the time of surgery, unidentified terminal branches can still result in a chyle leak . A chyle leak can be diagnosed clinically; however, blood investigation may be helpful for doubtful cases. Drain fluid on aspiration with a triglyceride level greater than 100 mg/dL or with the presence of chylomicrons are enough for the diagnosis of a chyle leak . Indication of re-exploration for chyle leak range from outputs of >500 mL/day to >1000 mL/day output for five days . When identified, the leaking thoracic duct can be ligated, covered with a muscle flap, or treated with any number of sclerosing agents, adhesive agents, or mesh . A suction drain must be placed after the case.
Conflict of Interest
The authors declare that they have no competing interests.
This work did not receive any specific grant from any funding agency in the public, commercial, or not-for-profit sector.
I declare that consent has been obtained from the patient or subject after a full explanation of the purpose and nature of all procedures used.I also declare that approval is not required in our study as the patient is notharmed during all procedures.
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